Project at a glance

RNA metabolism and bacterial pathogenesis

RNA metabolism, broadly defined as the series of processes that involve RNA in a cell—from synthesis to processing, translation, and degradation—significantly impacts the ability of bacteria to adapt and survive environmental challenges. Our research explores the role of RNA metabolism in bacterial pathogenesis, a field still in development but crucial for understanding bacterial infections. Our primary model is Pseudomonas aeruginosa, an ecologically versatile bacterium that thrives in various environments and is a leading cause of nosocomial infections worldwide. By studying RNA modification, processing, and degradation in P. aeruginosa, we aim to elucidate the key players and regulatory mechanisms that influence bacterial survival, virulence, and antibiotic resistance, ultimately advancing the development of new antimicrobial strategies.