Project at a glance

Identification of host and viral factors modulating viral pathogenicity, and search for antivirals

Viral infections are a major threat to global health, especially in vulnerable populations such as children and the elderly, leading to substantial morbidity and mortality. The emergence of SARS-CoV-2 has emphasized the critical need for effective antiviral therapies and vaccines. Our research aims to meet this demand using state-of-the-art methodologies. Utilizing in vitro reconstructed human tissue culture models, we recreate the complex physiological environment relevant to viral infections. Through transcriptomic and single-cell transcriptomic analyses of infected tissues, we are taking a closer look at the complex interplay between host responses and viral replication cycles, focusing particularly on respiratory and neurotropic infections.

These comprehensive analyses provide insights into viral evolution and adaptation, as well as the specific responses of infected tissues. By deciphering these mechanisms, we aim to identify novel targets for antiviral therapies, thus contributing to the development of effective strategies against viral infections.