Project at a glance

My lab uses the yeast S. cerevisiae model system to study mRNA biogenesis and export through nuclear pores and the importance of nuclear architecture in gene expression.

We currently focus on:

• the contribution of nuclear pores and the associated SUMO protease Ulp1 to transcription regulation,
• the role of ubiquitin in mRNP dynamics and surveillance along the gene expression pathway.

Another topic addresses the functional importance of non-coding antisense RNAs in epigenetic control of gene expression, using genome-wide and single cell (FISH) approaches, as well as genetic screens to identify the transacting factors involved in this RNAi-independent process.