Paul Guichard Group

Department of Molecular and Cellular Biology - Faculty of Science, University of Geneva

Department of Molecular and Cellular Biology
Sciences III - University of Geneva
Room 2017C - 2nd floor
30, quai Ernest-Ansermet
CH - 1211 Geneva 4

Phone: +41 (0)22 379 67 50
Fax: +41 (0)22 379 64 42

Paul Guichard
Associate professor

Project at a glance

Structural mechanisms governing centriole assembly

The centriole composes the centrosome in animal cells and can act as a basal body to template cilia or flagella in many eukaryotes. Centrioles are critical for the proper execution of several important biological processes, such as spindle assembly and cell signaling through the primary cilium as well as cells and fluids motion thanks to motile cilia/flagella. Therefore, centriolar defects have been associated to several pathologies including ciliopathies, sterility, microcephaly and cancer.

The lab focuses on deciphering the structural mechanisms governing centriole assembly. To this end, we are combining the use of cell biology methods, in vitro reconstitution assays and state-of-the art imaging technologies to gain decisive insights into these mechanisms.