Ivana Gasic Group

Department of Molecular and Cellular Biology - Faculty of Science, University of Geneva

Department of Molecular and Cellular Biology
Sciences III - University of Geneva
Room 1039B - 1st floor
30, quai Ernest-Ansermet
CH - 1211 Geneva 4

Phone: +41 (0)22 379 42 59
Fax: +41 (0)22 379 68 68

Ivana Gasic
Assistant professor

Project at a glance

Proteostasis and microtubule cytoskeleton

In our lab we challenge the central dogma postulating that regulation of gene expression and protein quantity is a unidirectional process. Our favourite proteins are tubulins - the main constituents of the microtubule cytoskeleton. We have recently shown how tubulin protein quantity feeds back into its encoding mRNA stability via a specificity factor.

Our goal is to dissect the molecular mechanisms that govern tubulin protein quantity control using biochemical and structural approaches, transcriptomics, and genome-wide screening. To address the functional aspects of protein quantity control, we deploy fluorescent imaging of live and fixed mammalian cultured cells.