David Shore Group
Department of Molecular Biology - Faculty of Science, University of Geneva
Project at a glance
Telomere biology and growth control of the ribosomal protein gene transcriptional network in yeast
We use the model eukaryote Saccharomyces cerevisiae (budding yeast) to address several specific areas of chromosome biology. Part of our group studies telomeres, the ends of linear chromosomes. We are interested in understanding:
- how telomeres are hidden from the DNA damage checkpoint and DNA repair mechanisms (capping function),
- how telomeres control in cis the telomerase enzyme, which prevents them from eroding by adding short repeat sequences onto chromosome ends,
- how telomeres exert a more global control over conventional DNA replication near chromosome ends.
A separate part of our group studies a transcriptional network involved in ribosome biogenesis, one of the major drivers of cell growth. We are interested in understanding in detail:
- how growth signals are transmitted to the promoters of the suite of 137 ribosomal protein genes,
- how the arrangement of transcription factors and nucleosomes at the promoters of these genes determines their transcriptional output.