Francesco Negro Group

Department of Internal Medicine Specialties & Department of Pathology and Immunology
Faculty of Medicine, University of Geneva & Geneva University Hospitals

Service of Gastroenterology and Hepatology
Geneva University Hospitals
4, rue Gabrielle-Perret-Gentil
CH – 1211 Geneva 14

Phone: +41 (0)22 372 93 55
Fax: +41 (0)22 372 93 66
Francesco.Negro@hcuge.ch

Francesco Negro
Full professor

Project at a glance

Study of the pathogenesis of chronic hepatitis C, including both hepatic and extrahepatic manifestations

A particular regard is given to:

  • HCV-induced fatty liver,
  • HCV-induced insulin resistance,
  • interactions between HCV and the metabolic syndrome,
  • factors/mechanisms of liver disease progression and resistance to interferon alpha-based antiviral therapy (particularly host genetic and metabolic factors).

The above research is carried out through the following approaches:

  • in vitro, using (i) different expression models of single HCV proteins (including lentivectors), (ii) full-length (infectious) HCV systems, (iii) co-cultures of HCV-expressing hepatoma cells with other celly types of major relevance in the pathogenesis of the metabolic syndrome;
  • in vivo, using human tissues (liver and peripheral blood mononuclear cells), taken in the setting of various observational and interventional clinical trials.

Organization and conduct of the Swiss Hepatitis C Cohort Study, currently established as Foundation.