Master student projects at the CMU - UNIGE
Laboratory of Prof. Marguerite Neerman-Arbez
Department of Genetic Medicine and Development
Faculty of Medicine
Translational research on disorders of hemostasis and thrombosis
We are looking for highly motivated master students in Biology or Biomedical Sciences interested in translating results obtained from basic medical science studies into better knowledge of patient phenotypes and personnalised treatments.
We are studying genetic disorders of hemostasis and thrombosis, applying the results of whole exome sequencing and functional analyses in transfected cells, zebrafish animal models and patient samples towards a personalised approach to treat these disorders.
Our main interest is in fibrinogen deficiencies, both quantitative and qualitative.
We investigate the molecular mechanisms by which fibrinogen gene mutations lead to disease and other mechanisms influencing the variable phenotypes of patients, including modifying gene polymorphisms.
Finally, we are studying novel mechanisms determining fibrinogen levels in the circulation, a project which is clinically relevant since a high fibrinogen level is an independent risk factor for cardiovascular disease.
Interested students should contact by email:
Circadian Endocrinology Lab - Dr. Charna Dibner
Department of Internal Medicine Specialty
& Department of Cell Physiology and Metabolism
Faculty of Medicine
The Dibner’s group studies the impact of biological clocks on metabolism, with particular focus on the roles of circadian oscillator in pancreatic islet and skeletal muscle function in physiology, and in etiology of obesity and type 2 diabetes.
We are looking for an ambitious MSc candidate, highly motivated and responsible, interested in working with mammalian, in particular human, primary cell cultures for the ongoing project, focusing on the input of human skeletal muscle clock into the lipid homeostasis, myokine secretion, and insulin sensitivity.
The study is performed in a close collaboration with the laboratory of Prof. Howard Riezman, Department of Biochemistry. The working languages in the laboratory are French and English. French skills, although helpful, are not essential.
Please send a complete CV including research interests, with a letter of motivation to:
Master student position
Laboratory of Sandra Citi
Department of Cell Biology – Faculty of Sciences
Investigating the molecular basis of hypertension
The Citi Laboratory investigates how junctional proteins in epithelial and endothelial cells control signaling, through the cytoskeleton, transcription factors, and membrane proteins.
Our laboratory discovered PLEKHA7, a cytoplasmic component of adherens junctions, which binds to paracingulin and to other cytoplasmic junctional proteins to stabilize adherin-based junctions.
PLEKHA7 has been found to be involved in cardiovascular physiology, hypertension and glaucome, through Genome-Wide Association Studies and genetic analysis. In rats Knock-Out for PLEKHA7, blood pressure is lower, and there is increased intracellular calcium and NO signaling by endothelial cells.
The proposed project addresses the role of PLEKHA7 in endothelial cells, using CRISPR-KO cellular and mouse models, and state-of-the art biochemical and cell biological techniques, to discover how PLEKHA7 is implicated in hypertension and vascular physiology.
Professor Sandra Citi
Master, PhD and post-doctoral positions
Various iGE3 members
- Master student - Patrick Meraldi Group, Faculty of MedicineAnnouncement
- Master student - Rabih Murr Group, Faculty of MedicineAnnouncement
- Master students - Serge Nef Group, Faculty of MedicineAnnouncement
- Master students - Xavier Perret Group, Faculty of ScienceAnnouncement
- Master students - Didier Picard Group, Faculty of ScienceAnnouncement
- Master student - PhD student - Post-doctoral fellows - Paul Guichard, Faculty of ScienceDetails
- Master students - PhD students - Post-doctoral fellows - Michel Milinkovitch, Faculty of ScienceDetails
- PhD students - Post-doctoral fellows - Thanos Halazonetis Group, Faculty of ScienceDetails
- PhD students - Post-doctoral fellows - Robbie Loewith Group, Faculty of ScienceDetails
- PhD students - Post-doctoral fellows - Ramesh Pillai Group, Faculty of ScienceDetails
- PhD student - Post-doctoral fellow - Florian Steiner Group, Faculty of ScienceDetails
- Post-doctoral fellows - Jean-Claude Martinou Group, Faculty of ScienceDetails
- Post-doctoral fellow - Didier Picard Group, Faculty of ScienceDetails