Circadian Endocrinology Lab - Dr. Charna Dibner
Department of Internal Medicine Specialty
& Department of Cell Physiology and Metabolism
Faculty of Medicine
The Dibner’s group studies the impact of biological clocks on metabolism, with particular focus on the roles of circadian oscillator in pancreatic islet and skeletal muscle function in physiology, and in etiology of obesity and type 2 diabetes.
We are looking for an ambitious MSc candidate, highly motivated and responsible, interested in working with mammalian, in particular human, primary cell cultures for the ongoing project, focusing on the input of human skeletal muscle clock into the lipid homeostasis, myokine secretion, and insulin sensitivity.
The study is performed in a close collaboration with the laboratory of Prof. Howard Riezman, Department of Biochemistry. The working languages in the laboratory are French and English. French skills, although helpful, are not essential.
Please send a complete CV including research interests, with a letter of motivation to:
Master student position
Laboratory of Sandra Citi
Department of Cell Biology – Faculty of Sciences
Investigating the molecular basis of hypertension
The Citi Laboratory investigates how junctional proteins in epithelial and endothelial cells control signaling, through the cytoskeleton, transcription factors, and membrane proteins.
Our laboratory discovered PLEKHA7, a cytoplasmic component of adherens junctions, which binds to paracingulin and to other cytoplasmic junctional proteins to stabilize adherin-based junctions.
PLEKHA7 has been found to be involved in cardiovascular physiology, hypertension and glaucome, through Genome-Wide Association Studies and genetic analysis. In rats Knock-Out for PLEKHA7, blood pressure is lower, and there is increased intracellular calcium and NO signaling by endothelial cells.
The proposed project addresses the role of PLEKHA7 in endothelial cells, using CRISPR-KO cellular and mouse models, and state-of-the art biochemical and cell biological techniques, to discover how PLEKHA7 is implicated in hypertension and vascular physiology.
Professor Sandra Citi