MSc position in Circadian Endocrinology Lab

A MSc position is available in the laboratory of Dr Charna Dibner

Division of Endocrinology, Diabetes and Nutrition - HUG
Department of Medicine & Department of Cell Physiology and Metabolism
Diabetes Center & iGE3
Faculty of Medicine - University of Geneva

The Dibner’s group studies the impact of biological clocks on metabolism, with particular focus on the roles of circadian oscillator in pancreatic islet and skeletal muscle function in physiology, and in etiology of obesity and type 2 diabetes.

We are looking for an ambitious MSc candidate, highly motivated and responsible, for the recently launched project, focusing on the interplay between the circadian clocks and eating patterns in patients with cardio-metabolic diseases. This patient-oriented project in the Dibner’s lab will center upon the work with human primary cell cultures, offering the candidate an opportunity to acquire the conceptual vision and methodological approaches related to primary cell culture, biochemistry and molecular biology, as well as state-of-the-art approaches to chronobiology. This multidisciplinary study will be conducted in a close collaboration with clinical endocrinologists, nutritionists, bioinformaticians, and geneticists, thus offering unconstrained possibilities for introduction to wider fields and expertises, and networking opportunities. Participation in alternative research projects undertaken in the laboratory can be considered, depending on the applicant’s interests. Excellent French level will be a plus.

Please send a complete CV including research interests, with a letter of motivation to:

Charna.Dibner@hcuge.ch
or
Charna.Dibner@unige.ch

Master student projects at the CMU - UNIGE

Laboratory of Prof. Marguerite Neerman-Arbez
Department of Genetic Medicine and Development
Faculty of Medicine

Translational research on disorders of hemostasis and thrombosis

We are looking for highly motivated master students in Biology or Biomedical Sciences interested in translating results obtained from basic medical science studies into better knowledge of patient phenotypes and personnalised treatments.

We are studying genetic disorders of hemostasis and thrombosis, applying the results of whole exome sequencing and functional analyses in transfected cells, zebrafish animal models and patient samples towards a personalised approach to treat these disorders. Our main interest is in fibrinogen deficiencies, both quantitative and qualitative. We investigate the molecular mechanisms by which fibrinogen gene mutations lead to disease and other mechanisms influencing the variable phenotypes of patients, including modifying gene polymorphisms. Finally, we are studying novel mechanisms determining fibrinogen levels in the circulation, a project which is clinically relevant since a high fibrinogen level is an independent risk factor for cardiovascular disease.

Interested students should contact by email:

Marguerite.Neerman-Arbez@unige.ch

Master student position

Laboratory of Sandra Citi
Department of Cell Biology – Faculty of Sciences

Investigating the molecular basis of hypertension

The Citi Laboratory investigates how junctional proteins in epithelial and endothelial cells control signaling, through the cytoskeleton, transcription factors, and membrane proteins. Our laboratory discovered PLEKHA7, a cytoplasmic component of adherens junctions, which binds to paracingulin and to other cytoplasmic junctional proteins to stabilize adherin-based junctions. PLEKHA7 has been found to be involved in cardiovascular physiology, hypertension and glaucome, through Genome-Wide Association Studies and genetic analysis. In rats Knock-Out for PLEKHA7, blood pressure is lower, and there is increased intracellular calcium and NO signaling by endothelial cells.

The proposed project addresses the role of PLEKHA7 in endothelial cells, using CRISPR-KO cellular and mouse models, and state-of-the art biochemical and cell biological techniques, to discover how PLEKHA7 is implicated in hypertension and vascular physiology.

Further information:
Professor Sandra Citi
Sandra.Citi@unige.ch

Master, PhD and post-doctoral positions

Various iGE3 members
  • Master student - Patrick Meraldi Group, Faculty of MedicineDetails
  • Master students - Xavier Perret Group, Faculty of ScienceAnnouncement
  • Master students - Didier Picard Group, Faculty of ScienceDetails
  • Master student - PhD students - Post-doctoral fellows - Paul Guichard, Faculty of ScienceDetails
  • Master students - PhD students - Post-doctoral fellows - Michel Milinkovitch, Faculty of ScienceDetails
  • PhD students - Post-doctoral fellows - Thanos Halazonetis Group, Faculty of ScienceDetails
  • PhD students - Post-doctoral fellows - Robbie Loewith Group, Faculty of ScienceDetails
  • PhD students - Post-doctoral fellows - Ramesh Pillai Group, Faculty of ScienceDetails
  • PhD student - Post-doctoral fellows - Florian Steiner Group, Faculty of ScienceDetails